HPE ProLiant DL380 Gen10
The HPE ProLiant DL380 Gen10 is one of the most widely deployed 2U dual-socket enterprise rack servers globally. Designed around the Intel Xeon Scalable 1st and 2nd Generation processors, it introduced Silicon Root of Trust security, persistent memory support, and flexible Smart Carrier drive configurations. Because thousands of enterprises standardized on this platform for enterprise virtualization, software-defined storage, and structured databases, it remains one of the highest-volume workhorses traded in secondary IT markets.
Also written as: DL380 G10, DL380Gen10, ProLiant DL380 Gen 10
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Jul 2017 |
| End of sale | Oct 2023 |
| End of support | Oct 2028 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon Scalable 1st Gen (Skylake) and 2nd Gen (Cascade Lake) |
| Memory slots | 24 |
| Memory type | DDR4-2666 / DDR4-2933 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 3,072 |
| Drive bays | Up to 24 SFF SAS/SATA, 12 LFF SAS/SATA, or up to 20 NVMe PCIe SSDs |
| Pcie slots | Up to 8 PCIe 3.0 expansion slots via primary and secondary risers |
| Gpu support | Up to 3 double-width or 5 single-width full-length GPUs |
| Network onboard | Embedded 4x 1GbE 331i network adapter plus FlexibleLOM slot |
| Power supply | HPE 500W, 800W, or 1600W Flex Slot Platinum hot-plug power supplies |
Generations
- Previous generation: HPE Proliant DL380 Gen9
- Next generation: HPE ProLiant DL380 Gen10 Plus
Reference prices (last 14 days, updated 2026-10-27)
Refurbished: USD 1,250 to 1,850 (2 sightings, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| servermonkey.com | refurbished | USD 1,250 | base 2x 4110 32GB 8SFF | 2026-10-27 |
| serversupply.com | refurbished | USD 1,850 | configured with 2x Silver 4210R, 64GB RAM | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
RAID controllers
- 804331-B21 HPE Smart Array P408i-a SR Gen10 12G SAS Modular Controller
Memory
- 815098-B21 HPE 16GB (1x16GB) Single Rank x4 DDR4-2666 CAS-19-19-19 Registered Smart Memory Kit
- 815100-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2666 CAS-19-19-19 Registered Smart Memory Kit
- P00924-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2933 CAS-21-21-21 Registered Smart Memory Kit
- P11040-B21 HPE 128GB (1x128GB) Quad Rank x4 DDR4-2933 CAS-21-21-21 Load Reduced Smart Memory Kit
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865408-B21 HPE 500W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865414-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865428-B21 HPE 800W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
- 865438-B21 HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
Hard drives
- 872477-B21 HPE 600GB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
- 872479-B21 HPE 1.2TB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
Equivalent models from other brands
- Dell Poweredge R740
- Lenovo ThinkSystem SR650 · compare
- Cisco Ucs C240 M5
Buying a used DL380 Gen10: what to check
When purchasing used DL380 Gen10 units, inspect whether the FlexibleLOM or PCIe NICs are included, confirm the Smart Array battery capacitor condition (P408i-a), check the iLO 5 Advanced license status, and ensure drives use standard HPE Smart Carriers (SC) rather than older Gen9 or newer Gen11 Basic Carriers.
FAQ
What processors are supported in the DL380 Gen10?
The DL380 Gen10 supports 1st Generation (Skylake-SP, 8100/6100/5100/4100 series) and 2nd Generation (Cascade Lake-SP, 8200/6200/5200/4200 series) Intel Xeon Scalable processors up to 28 cores per socket.
Can I use DDR5 memory in a DL380 Gen10?
No. The Gen10 platform is strictly DDR4, supporting 24 DIMM slots with speeds up to 2666 MT/s with 1st Gen Xeon or 2933 MT/s with 2nd Gen Xeon CPUs.
What drive carriers does the DL380 Gen10 use?
It uses HPE Smart Carrier (SC) trays with status LEDs. It cannot use Gen11 Basic Carrier (BC) trays.
Buying or selling DL380 Gen10?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL380 Gen10 Server QuickSpecs, checked 2026-10-27