HPE ProLiant DL380 Gen10 Plus
The HPE ProLiant DL380 Gen10 Plus acts as the transition platform between the classic Gen10 and Gen11 architectures, adopting 3rd Generation Intel Xeon Scalable Ice Lake processors. It introduced PCIe 4.0 across all lanes, 32 memory channels reaching up to 8TB of memory capacity, tri-mode U.3 backplane support, and the OCP 3.0 network form factor. It provides enterprise data centers with significant bandwidth increases without having to make the initial costly leap to DDR5 memory platforms.
Also written as: DL380 G10+, DL380Gen10Plus, ProLiant DL380 Gen10 Plus
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Apr 2021 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon Scalable 3rd Gen (Ice Lake-SP) |
| Memory slots | 32 |
| Memory type | DDR4-3200 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 8,192 |
| Drive bays | Up to 24 SFF SAS/SATA/NVMe U.3 or 12 LFF SAS/SATA, plus 2 rear SFF |
| Pcie slots | Up to 8 PCIe 4.0 expansion slots |
| Gpu support | Up to 3 double-wide or 8 single-wide PCIe accelerators |
| Network onboard | OCP 3.0 Gen4 slot plus optional FlexibleLOM riser adapter; 1Gb iLO 5 management port |
| Power supply | HPE 800W or 1600W Flex Slot Platinum hot-plug redundant power supplies |
Generations
- Previous generation: HPE ProLiant DL380 Gen10
- Next generation: HPE ProLiant DL380 Gen11
Reference prices (last 14 days, updated 2026-10-27)
Refurbished: USD 2,400 (1 sighting, Oct 2026)
Used: USD 1,950 (1 sighting, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| serversupply.com | refurbished | USD 2,400 | 2x Xeon Silver 4314, 64GB DDR4, 8SFF | 2026-10-27 |
| servermonkey.com | used | USD 1,950 | bare chassis with dual heatsinks and 800W PSUs | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865408-B21 HPE 500W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865414-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865428-B21 HPE 800W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
- 865438-B21 HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
- P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
Hard drives
- 872477-B21 HPE 600GB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
- 872479-B21 HPE 1.2TB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
Memory
- P06039-B21 HPE 256GB (1x256GB) Octal Rank x4 DDR4-3200 CAS-26-22-22 Load Reduced 3DS Smart Memory Kit
Boot devices
- P12965-B21 HPE NS204i-p Gen10 Plus NVMe PCIe OS Boot Device
Network adapters
- P26256-B21 HPE Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter
SSDs
- P40506-B21 HPE 960GB SAS 12G Read Intensive SFF BC Value SAS Multi Vendor SSD
- P50229-B21 HPE 3.2TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
Equivalent models from other brands
- Dell Poweredge R750
- Lenovo ThinkSystem SR650 V2 · compare
- Cisco Ucs C240 M6
Buying a used DL380 Gen10 Plus: what to check
Confirm whether the backplane installed is Tri-Mode (U.3 NVMe/SAS/SATA) or standard SAS/SATA. Check for proper heatsinks (standard vs. high-performance) if upgrading to higher-wattage 3rd Gen Xeon Platinum CPUs, verify iLO 5 licensing, and ensure drive caddies match the Smart Carrier standard.
FAQ
What is the difference between the DL380 Gen10 and DL380 Gen10 Plus?
The Gen10 Plus upgrades to 3rd Gen Intel Xeon Scalable processors (Ice Lake), PCIe 4.0 connectivity, 32 DIMM slots (up from 24), up to 3200 MT/s DDR4 speeds, and OCP 3.0 networking.
Does the DL380 Gen10 Plus support NVMe Gen4 drives?
Yes, with the appropriate Tri-Mode U.3 backplane and Tri-Mode controller (such as the MR416i-p or SR416i-a), it fully supports PCIe 4.0 NVMe drives.
What network cards fit in the DL380 Gen10 Plus?
The primary mezzanine slot is OCP 3.0, though standard PCIe add-in cards can be installed in riser slots.
Buying or selling DL380 Gen10 Plus?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL380 Gen10 Plus Server QuickSpecs, checked 2026-10-27