HPE ProLiant DL380 Gen11
The DL380 Gen11 is HPE's mainstream two-socket 2U rack server for the Sapphire Rapids and Emerald Rapids generation of Xeon processors. It is the box most enterprises standardise on for virtualisation, databases and general workloads, which is why it is also the most traded HPE model on the second-hand market. Compared with the Gen10 Plus it moves to DDR5 memory, PCIe Gen5 and U.3 tri-mode drive bays, and the LOM moves to an OCP 3.0 slot. Buyers of used units should check the iLO 6 Advanced licence, the installed MR or SR controller (the MR416i-p is the common one), the drive carriers and whether the Smart Array battery is present.
Also written as: DL380 G11, DL380Gen11, ProLiant DL380 Gen 11, P52560-B21
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Jan 2023 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon Scalable 4th Gen (Sapphire Rapids) and 5th Gen (Emerald Rapids) |
| Memory slots | 32 |
| Memory type | DDR5-4800 / DDR5-5600 RDIMM |
| Memory max (GB) | 8,192 |
| Drive bays | Up to 24 SFF (SAS/SATA/NVMe U.3) or 12 LFF, plus rear 2 SFF; 20 EDSFF E3.S option |
| Pcie slots | Up to 8 PCIe Gen5 slots via 3 risers |
| Gpu support | Up to 3 double-wide or 8 single-wide GPUs |
| Network onboard | OCP 3.0 slot (no fixed LOM); 1Gb iLO 6 management port |
| Power supply | Flex slot 800W / 1000W / 1600W / 1800-2200W, 1+1 redundant |
Generations
- Previous generation: HPE ProLiant DL380 Gen10 Plus
- Next generation: HPE Proliant DL380 Gen12
Compatible parts
Boot devices
- P12965-B21 HPE NS204i-p Gen10 Plus NVMe PCIe OS Boot Device
- P48183-B21 HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device
- P78279-B21 HPE NS204i-u V2 NVMe Hot Plug Boot Optimized Storage Device
- P81160-B21 HPE NS204i-u V2 960GB NVMe Hot Plug Boot Optimized Storage Device
Network adapters
- P26256-B21 HPE Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter
Power supplies
- P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
SSDs
- P40499-B21 HPE 1.92TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40500-B21 HPE 3.84TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40501-B21 HPE 7.68TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40504-B21 HPE 1.92TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P40505-B21 HPE 3.84TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P40506-B21 HPE 960GB SAS 12G Read Intensive SFF BC Value SAS Multi Vendor SSD
- P50227-B21 HPE 1.6TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
- P50229-B21 HPE 3.2TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
- P63829-B21 HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 CM7 SSD
- P64999-B21 HPE 800GB NVMe Gen4 Mainstream Performance Mixed Use SFF BC U.3 Static V2 SSD
- P65007-B21 HPE 1.6TB NVMe Gen4 Mainstream Performance Mixed Use SFF BC U.3 SSD
RAID controllers
- P47777-B21 HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Storage Controller
- P47781-B21 HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller
- P47785-B21 HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Storage Controller
- P47789-B21 HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller
- P58335-B21 HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
Memory
- P64705-B21 HPE 16GB (1x16GB) Single Rank x8 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64706-B21 HPE 32GB (1x32GB) Single Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64707-B21 HPE 64GB 2Rx4 DDR5-5600 SmartMemory RDIMM
- P64708-B21 HPE 96GB (1x96GB) Dual Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
CPUs
- P74503-B21 HPE ProLiant Intel Xeon 6505P 12-Core 2.2GHz 150W Processor Kit
Equivalent models from other brands
- Dell Poweredge R760
- Lenovo ThinkSystem SR650 V3 · compare
- H3C Uniserver R4900 G6
Buying a used DL380 Gen11: what to check
Confirm iLO 6 licence state, controller type (MR408i-o, MR416i-p or SR932i-p), presence of drive caddies and rails, PSU wattage, and that the CPUs match the heatsink type (standard vs. high-performance).
FAQ
What CPUs does the DL380 Gen11 support?
Intel Xeon Scalable 4th Gen (Sapphire Rapids, 8400 series) and, after the 2024 refresh, 5th Gen (Emerald Rapids, 8500 series) in one or two sockets.
How much memory does the DL380 Gen11 take?
32 DIMM slots, DDR5 RDIMM up to 8TB with 256GB modules. Speed is 4800 with 4th Gen and 5600 with 5th Gen CPUs.
What replaced the DL380 Gen11?
The DL380 Gen12 (2025) with Intel Xeon 6 processors. The Gen11 remains in sale alongside it.
Buying or selling DL380 Gen11?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL380 Gen11 QuickSpecs, checked 2026-10-27