Cisco HyperFlex HX245c M6
The Cisco HyperFlex HX245c M6 was a 2U storage-dense hyperconverged infrastructure node powered by 3rd Gen AMD EPYC processors. Designed to run Cisco HXDP software with up to 28 NVMe solid-state drives, it combined high core density with multi-petabyte distributed storage for big data and private cloud environments.
Specifications
| Brand | Cisco |
|---|---|
| Family | HyperFlex HX |
| Form factor | 2U rack |
| Released | Jun 2021 |
| End of sale | Mar 2024 |
| End of support | Mar 2029 |
| Processor | Up to 2x AMD EPYC 7003 series processors up to 64 cores each |
| Memory | 32x DDR4 DIMM slots supporting up to 8TB |
| Storage capacity | Up to 28x NVMe SSDs in 2U chassis |
| Hyperconverged software | Cisco HyperFlex Data Platform (HXDP) |
| Network | Cisco VIC 1467 and OCP 3.0 supporting up to 100GbE |
| Management | Cisco Intersight and VMware vCenter |
Works together
How the Cisco HyperFlex HX245c M6 connects to servers, storage and the network: 1 way, with the parts and products on each path.
Hyperconverged cluster
Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.
Adapters for the server
UCSC-O-ID10GC-D Cisco Intel X710T2LOCPV3G1L 2x10GbE RJ45 OCP 3.0 NIC
UCSC-O-ID25GF Cisco Intel XXV710DA2OCP1 2x25/10GbE OCP 2.0
UCSC-PCIE-E14102 Cisco Emulex OCe14102-FX dual-port 10 GbE FCoE CNA
UCSC-PCIE-Q8362 Cisco Qlogic QLE8362 dual-port 10 GbE FCoE CNA
Switches
Cisco Nexus 93180YC-FX3 1U
Cisco Nexus 93108TC-FX3P 1U fixed switch
Cisco Nexus 9332D-GX2B 1U fixed switch
Cisco Nexus 9364C-GX 2U fixed switch
Optics
QSFP-100G-CWDM4-S Cisco 100GBASE-CWDM4 QSFP28 Optical Transceiver
QSFP-100G-LR4-S Cisco 100GBASE-LR4 QSFP28 Optical Transceiver
QSFP-100G-SR4-S Cisco 100GBASE-SR4 QSFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Hypervisor advisor: which platform fits you mrplanb.com
- VM platform Ledger: hypervisors scored mrplanb.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
Check compatibility with Cisco
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that Cisco has tested with the Cisco HyperFlex HX245c M6.
- Compatibility Cisco UCS Hardware Compatibility List
- Compatibility Cisco Optics-to-Device Compatibility Matrix
- Support Cisco Support and Downloads
Equivalent models from other brands
- Dell Vxrail P675F
- Lenovo ThinkAgile HX5520 · compare
FAQ
What processors did the HX245c M6 use?
The HX245c M6 used 3rd Gen AMD EPYC 7003 series processors with up to 64 cores per socket.
How many NVMe drives could be installed?
Up to 28 front-accessible NVMe SSDs in a 2U rack form factor.
Buying or selling HyperFlex HX245c M6?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- Cisco HyperFlex HX245c M6 Spec Sheet, checked 2026-10-28