HPE ProLiant DL385 Gen10 Plus v2
The HPE ProLiant DL385 Gen10 Plus v2 is a dual-socket 2U AMD-based rack server engineered around the AMD EPYC 7003 (Milan and Milan-X) processors. It delivers up to 128 cores per chassis with 32 DDR4 memory channels and massive storage expandability (up to 32 SFF drive bays or 20 LFF bays). Because it pairs mature DDR4 memory costs with high-density EPYC core counts and full PCIe 4.0 expansion, it is widely utilized in enterprise virtualization and high-performance software-defined storage clusters.
Also written as: DL385 G10+ v2, DL385Gen10PlusV2, ProLiant DL385 Gen10 Plus v2
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Apr 2021 |
| Cpu sockets | 2 |
| Cpu platform | AMD EPYC 7003 (Milan) and 7002 (Rome) Series Processors |
| Memory slots | 32 |
| Memory type | DDR4-3200 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 8,192 |
| Drive bays | Up to 32 SFF SAS/SATA/NVMe, or 20 LFF SAS/SATA |
| Pcie slots | Up to 8 PCIe 4.0 expansion slots |
| Gpu support | Up to 3 double-wide or 8 single-wide PCIe GPUs |
| Network onboard | OCP 3.0 Gen4 slot; 1Gb iLO 5 management port |
| Power supply | Flex Slot 500W, 800W, or 1600W hot-plug Platinum/Titanium redundant power supplies |
Generations
- Previous generation: HPE Proliant DL385 Gen10
- Next generation: HPE ProLiant DL385 Gen11
Reference prices (last 14 days, updated 2026-10-27)
Refurbished: USD 2,850 (1 sighting, Oct 2026)
Used: USD 1,950 (1 sighting, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| serversupply.com | refurbished | USD 2,850 | 2x EPYC 7313 16C, 64GB DDR4, 8SFF | 2026-10-27 |
| servermonkey.com | used | USD 1,950 | barebone chassis with 800W PSUs | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
Memory
- 815100-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2666 CAS-19-19-19 Registered Smart Memory Kit
- P06039-B21 HPE 256GB (1x256GB) Octal Rank x4 DDR4-3200 CAS-26-22-22 Load Reduced 3DS Smart Memory Kit
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865414-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865428-B21 HPE 800W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
- 865438-B21 HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
- P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
Hard drives
- 872477-B21 HPE 600GB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
- 872479-B21 HPE 1.2TB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
Network adapters
- P26256-B21 HPE Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter
Equivalent models from other brands
- Dell Poweredge R7525
- Lenovo ThinkSystem SR665 · compare
Buying a used DL385 Gen10 Plus v2: what to check
Confirm processor vendor locks: AMD EPYC processors initialized in HPE servers are cryptographically locked with HPE PSB (Platform Secure Boot) and cannot be moved to Dell or Supermicro systems. Check whether standard or high-performance heatsinks are installed, and verify backplane cabling configurations.
FAQ
What is the difference between DL385 Gen10 Plus and v2?
The v2 motherboard supports 3rd Gen AMD EPYC 7003 series (Milan/Milan-X) out of the box with improved power delivery and higher maximum TDP support (up to 280W).
Can AMD processors from an HPE server be used in other brands?
No. HPE enables AMD Platform Secure Boot (PSB), which permanently fuses the processor to HPE hardware once powered on.
How many drive bays can the DL385 Gen10 Plus v2 support?
Up to 32 SFF or 20 LFF drives, making it one of the highest-density storage chassis in the 2U ProLiant series.
Buying or selling DL385 Gen10 Plus v2?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL385 Gen10 Plus v2 Server QuickSpecs, checked 2026-10-27