HPE ProLiant DL385 Gen11
The HPE ProLiant DL385 Gen11 is a high-density, dual-socket 2U rack server powered by AMD EPYC 9004 and 9005 series processors. It offers unmatched core density with up to 128 cores per socket (256 cores per server) on 4th Gen EPYC and even higher on 5th Gen, combined with 24 channels of high-speed DDR5 memory and up to 128 lanes of PCIe Gen5. It is heavily utilized for large-scale enterprise virtualization consolidation, deep database indexing, and memory-intensive artificial intelligence inferencing.
Also written as: DL385 G11, DL385Gen11, ProLiant DL385 Gen 11
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Nov 2022 |
| Cpu sockets | 2 |
| Cpu platform | AMD EPYC 9004 / 9005 Series Processors (Genoa, Bergamo, Turin) |
| Memory slots | 24 |
| Memory type | DDR5-4800 / DDR5-5200 / DDR5-6000 SmartMemory RDIMM |
| Memory max (GB) | 6,144 |
| Drive bays | Up to 24 SFF SAS/SATA/NVMe U.3 or 12 LFF SAS/SATA; EDSFF E3.S options |
| Pcie slots | Up to 8 PCIe 5.0 slots plus 2 OCP 3.0 slots |
| Gpu support | Up to 4 double-wide or 8 single-wide PCIe accelerators |
| Network onboard | Dual OCP 3.0 Gen5 slots; 1Gb dedicated iLO 6 management port |
| Power supply | HPE 800W, 1000W, or 1600W Flex Slot Platinum hot-plug redundant power supplies |
Generations
- Previous generation: HPE ProLiant DL385 Gen10 Plus v2
Reference prices (last 14 days, updated 2026-10-27)
New: USD 4,850 (1 sighting, Oct 2026)
Refurbished: USD 14,200 (1 sighting, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| cdw.com | new | USD 4,850 | Base CTO chassis without CPUs or memory | 2026-10-27 |
| serversupply.com | refurbished | USD 14,200 | 2x AMD EPYC 9354, 128GB DDR5, 8SFF | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865438-B21 HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
- P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
Boot devices
- P12965-B21 HPE NS204i-p Gen10 Plus NVMe PCIe OS Boot Device
- P48183-B21 HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device
- P78279-B21 HPE NS204i-u V2 NVMe Hot Plug Boot Optimized Storage Device
- P81160-B21 HPE NS204i-u V2 960GB NVMe Hot Plug Boot Optimized Storage Device
Network adapters
- P26256-B21 HPE Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter
SSDs
- P40499-B21 HPE 1.92TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40500-B21 HPE 3.84TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40501-B21 HPE 7.68TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40504-B21 HPE 1.92TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P40505-B21 HPE 3.84TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P40506-B21 HPE 960GB SAS 12G Read Intensive SFF BC Value SAS Multi Vendor SSD
- P50227-B21 HPE 1.6TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
- P50229-B21 HPE 3.2TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
- P64999-B21 HPE 800GB NVMe Gen4 Mainstream Performance Mixed Use SFF BC U.3 Static V2 SSD
- P65007-B21 HPE 1.6TB NVMe Gen4 Mainstream Performance Mixed Use SFF BC U.3 SSD
- P63829-B21 HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 CM7 SSD
RAID controllers
- P47777-B21 HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Storage Controller
- P47781-B21 HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller
- P47785-B21 HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Storage Controller
- P47789-B21 HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller
- P58335-B21 HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
Memory
- P64705-B21 HPE 16GB (1x16GB) Single Rank x8 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64706-B21 HPE 32GB (1x32GB) Single Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64707-B21 HPE 64GB 2Rx4 DDR5-5600 SmartMemory RDIMM
- P64708-B21 HPE 96GB (1x96GB) Dual Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
Equivalent models from other brands
- Dell Poweredge R7625
- Lenovo ThinkSystem SR665 V3 · compare
Buying a used DL385 Gen11: what to check
Verify processor thermal requirements, as high-core AMD EPYC 9004 series CPUs (over 300W TDP) require specialized high-performance heatsinks and closed-loop liquid cooling options. Ensure the power supplies meet total system draw (often dual 1600W units are necessary), and confirm memory configurations match balanced 12-channel per socket population rules.
FAQ
What processors are compatible with the DL385 Gen11?
The DL385 Gen11 supports AMD EPYC 9004 (Genoa / Bergamo) and next-generation 9005 (Turin) series processors in single or dual socket configurations.
How many memory channels does the DL385 Gen11 have?
It features 12 memory channels per processor socket, with 1 DIMM per channel across 24 total DDR5 slots.
Does the DL385 Gen11 support GPUs?
Yes, it supports up to 4 double-wide or 8 single-wide PCIe accelerators (such as NVIDIA L40S or A100).
Buying or selling DL385 Gen11?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL385 Gen11 Server QuickSpecs, checked 2026-10-27