HPE ProLiant ML350 Gen10
The HPE ProLiant ML350 Gen10 is a versatile dual-socket 4U tower server delivering enterprise-level performance, storage capacity, and security for branch offices, growing businesses, and specialized industrial facilities. Featuring 1st and 2nd Gen Intel Xeon Scalable processors, 24 DDR4 DIMM slots, and flexible internal storage for up to 24 SFF drives, it offers quiet acoustics suitable for office deployment alongside full 4U rack-mount conversion capability.
Also written as: ML350 G10, ML350Gen10, ProLiant ML350 Gen 10
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant ML |
| Form factor | 4U tower |
| Released | Jul 2017 |
| End of sale | Oct 2023 |
| End of support | Oct 2028 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon Scalable 1st Gen (Skylake) and 2nd Gen (Cascade Lake) |
| Memory slots | 24 |
| Memory type | DDR4-2666 / DDR4-2933 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 3,072 |
| Drive bays | Up to 24 SFF SAS/SATA/NVMe or 12 LFF SAS/SATA |
| Pcie slots | Up to 8 PCIe 3.0 expansion slots |
| Gpu support | Up to 4 double-wide or 8 single-wide PCIe GPUs |
| Network onboard | Embedded 4x 1GbE 369i network adapter; dedicated iLO 5 management port |
| Power supply | Flex Slot 500W, 800W, or 1600W hot-plug Platinum redundant power supplies |
Generations
- Previous generation: HPE Proliant ML350 Gen9
- Next generation: HPE ProLiant ML350 Gen11
Reference prices (last 14 days, updated 2026-10-27)
Refurbished: USD 1,450 to 1,850 (2 sightings, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| servermonkey.com | refurbished | USD 1,450 | 2x Xeon Silver 4110, 32GB RAM, 8SFF tower | 2026-10-27 |
| serversupply.com | refurbished | USD 1,850 | 2x Xeon Silver 4210, 64GB DDR4 | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
RAID controllers
- 804331-B21 HPE Smart Array P408i-a SR Gen10 12G SAS Modular Controller
Memory
- 815098-B21 HPE 16GB (1x16GB) Single Rank x4 DDR4-2666 CAS-19-19-19 Registered Smart Memory Kit
- 815100-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2666 CAS-19-19-19 Registered Smart Memory Kit
- P00924-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2933 CAS-21-21-21 Registered Smart Memory Kit
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865408-B21 HPE 500W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865414-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- 865428-B21 HPE 800W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
- 865438-B21 HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
Hard drives
- 872477-B21 HPE 600GB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
- 872479-B21 HPE 1.2TB SAS 12G Enterprise 10K SFF SC Digitally Signed Firmware HDD
Equivalent models from other brands
- Dell Poweredge T640
- Lenovo ThinkSystem ST550 · compare
Buying a used ML350 Gen10: what to check
Confirm whether the tower chassis includes original desktop feet and lockable front door or the 4U rackmount conversion kit. Test the condition of the Smart Array battery capacitor (P408i-a), check the wattage on the installed Flex Slot power supplies, and verify that all memory channels operate cleanly.
FAQ
Does the ML350 Gen10 support rack mounting?
Yes. It can be rack mounted using the HPE ML350 Gen10 Tower-to-Rack Conversion Kit, occupying 4U of rack space.
Can the ML350 Gen10 run GPUs?
Yes, it supports up to 4 double-wide or 8 single-wide GPU cards, though high-wattage configurations require 800W or 1600W power supplies and redundant fan kits.
What drive trays fit in the ML350 Gen10?
It uses standard HPE Smart Carrier (SC) trays for both 2.5-inch SFF and 3.5-inch LFF configurations.
Buying or selling ML350 Gen10?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant ML350 Gen10 Server QuickSpecs, checked 2026-10-27