HPE ProLiant ML350 Gen11
The HPE ProLiant ML350 Gen11 is a powerful dual-socket 4U tower and rack-convertible enterprise server engineered for remote and branch offices (ROBO), regional corporate headquarters, and growing data center deployments. Built on 4th and 5th Generation Intel Xeon Scalable processors, it supports 32 DDR5 memory channels, massive internal storage capacity (up to 24 SFF or 12 LFF drives), extensive PCIe 5.0 slot expandability, and full GPU accelerator support in a quiet acoustic chassis.
Also written as: ML350 G11, ML350Gen11, ProLiant ML350 Gen 11
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant ML |
| Form factor | 4U tower |
| Released | Mar 2023 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon Scalable 4th Gen (Sapphire Rapids) and 5th Gen (Emerald Rapids) |
| Memory slots | 32 |
| Memory type | DDR5-4800 / DDR5-5600 SmartMemory RDIMM |
| Memory max (GB) | 8,192 |
| Drive bays | Up to 24 SFF SAS/SATA/NVMe U.3 or 12 LFF SAS/SATA, plus media bays |
| Pcie slots | Up to 10 PCIe 5.0 / PCIe 4.0 expansion slots plus 1 OCP 3.0 slot |
| Gpu support | Up to 4 double-wide or 8 single-wide PCIe graphics accelerators |
| Network onboard | OCP 3.0 Gen5 slot (no embedded LOM); dedicated 1Gb iLO 6 management port |
| Power supply | Flex Slot 800W, 1000W, or 1600W hot-plug Platinum/Titanium redundant power supplies |
Generations
- Previous generation: HPE ProLiant ML350 Gen10
Reference prices (last 14 days, updated 2026-10-27)
New: USD 4,350 (1 sighting, Oct 2026)
Refurbished: USD 9,500 (1 sighting, Oct 2026)
All sightings
| Seller | Condition | Price | Note | Seen |
|---|---|---|---|---|
| cdw.com | new | USD 4,350 | Base CTO tower chassis | 2026-10-27 |
| serversupply.com | refurbished | USD 9,500 | 1x Xeon Silver 4410Y, 64GB DDR5, 8SFF | 2026-10-27 |
Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.
Compatible parts
Power supplies
- 830272-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
- P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
SSDs
- P40499-B21 HPE 1.92TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40500-B21 HPE 3.84TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40501-B21 HPE 7.68TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
- P40504-B21 HPE 1.92TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P40505-B21 HPE 3.84TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
- P63829-B21 HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 CM7 SSD
RAID controllers
- P47777-B21 HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Storage Controller
- P47785-B21 HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Storage Controller
Boot devices
- P48183-B21 HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device
Memory
- P64705-B21 HPE 16GB (1x16GB) Single Rank x8 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64706-B21 HPE 32GB (1x32GB) Single Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
- P64707-B21 HPE 64GB 2Rx4 DDR5-5600 SmartMemory RDIMM
- P64708-B21 HPE 96GB (1x96GB) Dual Rank x4 DDR5-5600 CAS-46-45-45 EC8 Registered Smart Memory Kit
CPUs
- P74503-B21 HPE ProLiant Intel Xeon 6505P 12-Core 2.2GHz 150W Processor Kit
Equivalent models from other brands
- Dell Poweredge T560
- Lenovo ThinkSystem ST650 V3 · compare
Buying a used ML350 Gen11: what to check
Check whether the server includes the tower feet and front security bezel or the 4U rack rail conversion kit, as running it in an enterprise rack requires dedicated conversion hardware. Ensure high-performance fan kits are included if installing high-wattage GPUs, verify power supply wattages, and confirm iLO 6 functionality.
FAQ
Can the ML350 Gen11 be converted from a tower into a rackmount server?
Yes. It can be converted into a standard 4U rackmount server using the official HPE ML350 Gen11 Tower to Rack Conversion Kit and rail kit.
How many GPUs can the ML350 Gen11 accommodate?
It can support up to 4 double-width or 8 single-width PCIe graphics accelerator cards, making it an excellent AI inferencing or VDI server for office environments.
What drive carriers does the ML350 Gen11 use?
It uses the new HPE Basic Carrier (BC) trays for both SFF and LFF drive bays.
Buying or selling ML350 Gen11?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant ML350 Gen11 Server QuickSpecs, checked 2026-10-27