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P43322-B21: HPE 16GB (1x16GB) Single Rank x8 DDR5-4800 CAS-40-39-39 EC8 Registered Smart Memory Kit

HPE P43322-B21 Memory4800 MT/s
HPEMemory

Also listed as: P46626-001, P43016-001, M321R2GA3BB0-CQK, HMCG66AGBRA191N · made by Samsung

The HPE P43322-B21 is an entry-tier 16GB single-rank DDR5-4800 ECC registered SmartMemory kit designed for HPE ProLiant Gen11 servers. Built on advanced 16Gb DDR5 DRAM architecture, it provides 4800 MT/s transfer speeds with an ultra-efficient 1.1V operating voltage, integrated on-DIMM Power Management IC (PMIC), and dual 32-bit subchannels for enhanced data concurrency.

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Specifications

Part numberP43322-B21
BrandHPE
Made bySamsung
TypeMemory
Other numbersP46626-001, P43016-001, M321R2GA3BB0-CQK, HMCG66AGBRA191N
Statuscurrent
Capacity16GB
TypeDDR5-4800 Registered DIMM (RDIMM)
Speed4800 MT/s (PC5-38400)
Voltage1.1V
RankSingle Rank (1Rx8)
Cas latency40-39-39
Generation fitProLiant Gen11 servers with 4th Gen Intel Xeon Scalable

About the P43322-B21

P43322-B21 is HPE's 16GB single-rank DDR5-4800 registered ECC SmartMemory kit for HPE ProLiant Gen11 servers. Powered by 4th Generation Intel Xeon Scalable (Sapphire Rapids) and AMD EPYC 9004 (Genoa) processors, DDR5 memory delivers double the burst length and 50% greater data rate compared to DDR4, backed by on-DIMM PMIC power regulation.

Compatibility

Engineered and qualified for HPE ProLiant Gen11 platforms including DL380 Gen11, DL360 Gen11, DL385 Gen11, DL325 Gen11, DL345 Gen11, DL365 Gen11, DL560 Gen11, ML350 Gen11, ML110 Gen11, and Synergy 480 Gen11. Does not install into DDR4-based Gen10 or Gen10 Plus motherboards due to distinct physical keying.

How to identify a genuine unit

288-pin DDR5 registered DIMM with center-positioned onboard PMIC and dual power inductors on a dark green PCB. Barcode label indicates option part number P43322-B21, spare part number P46626-001, and assembly part number P43016-001 with holographic genuine HPE seal.

Buying used

Inspect the center PMIC module and surrounding power circuitry for physical impacts or cracked solder joints. Ensure gold edge connector fingers have intact plating. Validate via HPE iLO 6 that the module is authenticated as genuine HPE SmartMemory with normal PMIC operating temperatures.

Reference prices (last 12 months, updated 2026-10-27)

Used: USD 78 (1 sighting, Oct 2026)

All sightings
SellerConditionPriceNoteSeen
ebay.comusedUSD 78Tested working HPE 16GB 1Rx8 DDR5-4800 RDIMM pull2026-10-27

Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.

Fits these models

Check compatibility with HPE

Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE P43322-B21.

Equivalent part numbers

FAQ

What architectural improvements does DDR5 introduce over DDR4?

DDR5 splits each 64-bit channel into two independent 32-bit subchannels, introduces on-die ECC alongside sideband EC8, and integrates an onboard PMIC for localized voltage regulation.

Can DDR5-4800 memory be mixed with DDR5-5600 memory?

Mixing DDR5-4800 and DDR5-5600 modules within the same server causes the memory subsystem to operate uniformly at 4800 MT/s.

Buying or selling P43322-B21?

New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.

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