Home › Parts › HPE part numbers

P43331-B21: HPE 64GB (1x64GB) Dual Rank x4 DDR5-4800 CAS-40-39-39 EC8 Registered Smart Memory Kit

HPE P43331-B21 Memory4800 MT/s
HPEMemory

Also listed as: P46631-001, P43021-001, M321R8GA0BB0-CQK, HMCG98AGB084N · made by Samsung

The HPE P43331-B21 is a high-capacity 64GB dual-rank DDR5-4800 ECC registered SmartMemory DIMM kit engineered for compute-heavy HPE ProLiant Gen11 servers. It enables memory capacities up to 4TB per dual-socket node across 16 channels, providing enterprise virtualization nodes, large container hosts, and SQL/Oracle database servers with high bandwidth and density.

Buy P43331-B21Sell yours

Specifications

Part numberP43331-B21
BrandHPE
Made bySamsung
TypeMemory
Other numbersP46631-001, P43021-001, M321R8GA0BB0-CQK, HMCG98AGB084N
Statuscurrent
Capacity64GB
TypeDDR5-4800 Registered DIMM (RDIMM)
Speed4800 MT/s (PC5-38400)
Voltage1.1V
RankDual Rank (2Rx4)
Cas latency40-39-39
Generation fitProLiant Gen11 servers with 4th Gen Intel Xeon Scalable

About the P43331-B21

P43331-B21 is HPE's 64GB dual-rank DDR5-4800 ECC registered SmartMemory DIMM designed for high-capacity workload demands in ProLiant Gen11 servers. Utilizing 16Gb DRAM dies configured in dual ranks, it maximizes per-channel memory density while providing high bandwidth across 8-channel and 12-channel server CPU sockets.

Compatibility

Compatible across HPE ProLiant Gen11 servers including DL380 Gen11, DL360 Gen11, DL385 Gen11, DL325 Gen11, DL345 Gen11, DL365 Gen11, DL560 Gen11, ML350 Gen11, ML110 Gen11, and Synergy 480 Gen11. Does not install into older Gen10 or Gen10 Plus architectures due to DDR5 notch keying differences.

How to identify a genuine unit

288-pin DDR5 registered DIMM with center-mounted PMIC and dual onboard power inductors. White barcode label shows option part number P43331-B21, spare part number P46631-001, and assembly part number P43021-001 alongside the holographic genuine HPE security seal.

Buying used

Inspect module contacts for signs of physical wear, gouges, or contact contamination. Confirm that the central PMIC circuit shows no signs of overheating. Power on the system and verify via iLO 6 that SmartMemory authentication succeeds and no correctable error warnings are present.

Reference prices (last 12 months, updated 2026-10-27)

Used: USD 235 (1 sighting, Oct 2026)

All sightings
SellerConditionPriceNoteSeen
ebay.comusedUSD 235Tested working HPE 64GB 2Rx4 DDR5-4800 RDIMM2026-10-27

Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.

Fits these models

Check compatibility with HPE

Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE P43331-B21.

Equivalent part numbers

FAQ

What processors support P43331-B21?

Intel Xeon Scalable 4th Generation (Sapphire Rapids) and AMD EPYC 9004 Series (Genoa) processors natively support this 64GB DDR5-4800 module.

Does P43331-B21 operate with on-die ECC?

Yes, all DDR5 modules feature on-die ECC for internal DRAM integrity alongside system-level ECC (EC8) for bus transfer protection.

Buying or selling P43331-B21?

New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.

Buy P43331-B21Sell yours

Sources