Cisco HyperFlex HX220c M5
The Cisco HyperFlex HX220c M5 was a 1U hyperconverged infrastructure node powered by Intel Xeon Scalable processors and Cisco HyperFlex Data Platform (HXDP). Combining compute, high-performance flash storage, and unified software-defined networking in a 1U form factor, it simplified cluster deployment and management for virtualized data centers.
Specifications
| Brand | Cisco |
|---|---|
| Family | HyperFlex HX |
| Form factor | 1U rack |
| Released | Jul 2017 |
| End of sale | Mar 2023 |
| End of support | Mar 2028 |
| Processor | Up to 2x 1st or 2nd Gen Intel Xeon Scalable processors up to 28 cores each |
| Memory | Up to 24x DDR4 DIMM slots supporting up to 3TB |
| Storage capacity | Available in all-flash (up to 8x SSDs) and hybrid (1x SSD cache + 7x SAS HDDs) configurations |
| Hyperconverged software | Cisco HyperFlex Data Platform (HXDP) |
| Network | Cisco VIC 1387 / 1457 modular LOM providing unified fabric integration with UCS Fabric Interconnects |
| Management | Cisco Intersight and VMware vCenter integration |
Generations
- Next generation: Cisco HyperFlex HX220c M6
Compatible parts
Hard drives
HX-HD12TB10K12N Cisco 1.2TB 2.5 inch 12G SAS 10K RPM HDD
HX-HD18TB10K4KN Cisco 1.8 TB 12G SAS 10K RPM SFF HDD
SSDs
HX-M2-240GB Cisco 240GB SATA M.2 SSD
HX-SD240GM1X-EV Cisco 240GB 2.5 inch Enterprise Value 6G SATA SSD (HyperFlex Release
HX-SD480G63X-EP Cisco 480GB 2.5 inch Enterprise Performance 6G SATA SSD (3X endurance)
HX-SD800GK3X-EP Cisco 800GB 2.5 inch Enterprise Performance 12G SAS SSD (3X endurance)
Memory
HX-ML-X64G4RT-H Cisco 64 GB DDR4-2933MHz LRDIMM/4Rx4 (8Gb)
HX-MR-X16G1RT-H Cisco 16 GB DDR4-2933MHz RDIMM/1Rx4 (8Gb)
HX-MR-X32G2RT-H Cisco 32GB DDR4-2933MHz RDIMM/2Rx4 (8Gb)
HX-MR-X64G2RT-H Cisco 64 GB DDR4-2933MHz RDIMM/2Rx4 (16Gb)
HX-MR-X64G2RW Cisco 64GB DDR4-3200MHz RDIMM 2Rx4 (16Gb)
Network adapters
HX-MLOM-C25Q-04 Cisco UCS VIC 1457 Quad Port 10/25G SFP28 CNA MLOM
HX-MLOM-C40Q-03 Cisco VIC 1387 Dual Port 40Gb QSFP CNA MLOM
HX-PCIE-C25Q-04 Cisco UCS VIC 1455 Quad Port 10/25G SFP28 CNA PCIE
HX-PCIE-C40Q-03 Cisco VIC 1385 Dual Port 40Gb QSFP+ CNA w/RDMA
HX-PCIE-ID10GF Cisco Intel X710-DA2 Dual Port 10G SFP+ NIC
HX-PCIE-IRJ45 Cisco Intel i350 Quad Port 1Gb Adapter
Power supplies
HX-PSU1-1050W Cisco 1050W AC power supply for C-Series servers
HX-PSU1-770W Cisco 770W AC power supply for C-Series Servers
HX-PSUV2-1050DC Cisco 1050W DC power supply for C-Series servers
Rail kits
HX-RAILF-M4 Cisco Friction Rail Kit for C220 M4 rack servers
HBAs
HX-SAS-M5 Cisco 12G Modular SAS HBA (max 16 drives)
TPM modules
HX-TPM2-002 Cisco Trusted Platform Module 2.0 for UCS servers
Works together
How the Cisco HyperFlex HX220c M5 connects to servers, storage and the network: 1 way, with the parts and products on each path.
Hyperconverged cluster
Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.
Adapters for the server
UCSC-O-ID10GC-D Cisco Intel X710T2LOCPV3G1L 2x10GbE RJ45 OCP 3.0 NIC
UCSC-O-ID25GF Cisco Intel XXV710DA2OCP1 2x25/10GbE OCP 2.0
UCSC-PCIE-E14102 Cisco Emulex OCe14102-FX dual-port 10 GbE FCoE CNA
UCSC-PCIE-Q8362 Cisco Qlogic QLE8362 dual-port 10 GbE FCoE CNA
Switches
Cisco Nexus 93108TC-FX 1U fixed switch
Cisco Nexus 9364C 2U fixed switch
Cisco Nexus 31108PC-V 1U fixed switch
Cisco Nexus 34180YC 1U fixed switch
Optics
QSFP-100G-CWDM4-S Cisco 100GBASE-CWDM4 QSFP28 Optical Transceiver
QSFP-100G-LR4-S Cisco 100GBASE-LR4 QSFP28 Optical Transceiver
QSFP-100G-SR4-S Cisco 100GBASE-SR4 QSFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Hypervisor advisor: which platform fits you mrplanb.com
- VM platform Ledger: hypervisors scored mrplanb.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
Check compatibility with Cisco
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that Cisco has tested with the Cisco HyperFlex HX220c M5.
- Compatibility Cisco UCS Hardware Compatibility List
- Compatibility Cisco Optics-to-Device Compatibility Matrix
- Support Cisco Support and Downloads
Equivalent models from other brands
FAQ
What software provided distributed storage on the HX220c M5?
The Cisco HyperFlex Data Platform (HXDP) delivered distributed log-structured file system storage.
What successor replaced the HX220c M5?
The HyperFlex HX220c M6 replaced the HX220c M5.
Buying or selling HyperFlex HX220c M5?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- Cisco HyperFlex HX220c M5 Data Sheet, checked 2026-10-28
- Cisco HyperFlex HX220c M5 Node Spec Sheet, checked 2026-10-28