Cisco HyperFlex HX220c M6
The Cisco HyperFlex HX220c M6 was a 1U all-NVMe hyperconverged infrastructure node powered by 3rd Gen Intel Xeon Scalable processors. Engineered to run Cisco HyperFlex Data Platform, it delivered microsecond distributed storage latency, automated deduplication, and cloud lifecycle orchestration via Cisco Intersight.
Specifications
| Brand | Cisco |
|---|---|
| Family | HyperFlex HX |
| Form factor | 1U rack |
| Released | Apr 2021 |
| End of sale | Mar 2024 |
| End of support | Mar 2029 |
| Processor | Up to 2x 3rd Gen Intel Xeon Scalable processors up to 40 cores each |
| Memory | 32x DDR4 DIMM slots supporting up to 8TB |
| Storage capacity | All-NVMe configuration with up to 10x NVMe SSDs |
| Hyperconverged software | Cisco HyperFlex Data Platform (HXDP) |
| Network | Cisco VIC 1467 and OCP 3.0 supporting 100GbE unified fabric |
| Management | Cisco Intersight and VMware vCenter |
Generations
- Previous generation: Cisco HyperFlex HX220c M5
Compatible parts
Hard drives
HXE-HD24TB10K4KN Cisco HX Express 2.4 TB 12G SAS 10K RPM SFF HDD (4K)
Memory
HXE-MR-X64G2RW Cisco HX Express 64GB RDIMM DRx4 3200 (16Gb)
SSDs
HXE-NVME4-3840 Cisco HX Express 3.8TB2.5inU.2 P5520NVMeHighPerf Med Endur
HXE-NVMEI4-I3840 Cisco HX Express 3.8TB 2.5in U.2 Intel P5500 NVMe HPer MEnd
HXE-NVMEI4-I7680 Cisco HX Express 7.6TB 2.5in U.2 Intel P5500 NVMe HPer MEnd
HXE-NVMEM6-W15300 Cisco 15.3TB 2.5in U.2 WD SN840 NVMe Extreme Perf. High Endurance
HXE-SD38T61X-EV Cisco HX Express 3.8TB 2.5 inch Enterprise Value 6G SATA SSD
HXE-SD38T6S1X-EV Cisco HX Express 3.8TB 2.5inch Enterprise Value 6G SATA SSD
HXE-SD76T61X-EV Cisco HX Express 7.6TB 2.5 inch Enterprise Value 6G SATA SSD
Power supplies
HXE-PSU1-1050W Cisco HX Express 1050W AC PSU Platinum (Not EU/UK Lot 9 Compliant)
HXE-PSU1-1600W Cisco HX Express 1600W AC PSU Platinum (Not EU/UK Lot 9 Compliant)
HXE-PSUV2-1050DC Cisco HX Express 1050W -48V DC Power Supply for Rack Server
Works together
How the Cisco HyperFlex HX220c M6 connects to servers, storage and the network: 1 way, with the parts and products on each path.
Hyperconverged cluster
Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.
Adapters for the server
UCSC-O-ID10GC-D Cisco Intel X710T2LOCPV3G1L 2x10GbE RJ45 OCP 3.0 NIC
UCSC-O-ID25GF Cisco Intel XXV710DA2OCP1 2x25/10GbE OCP 2.0
UCSC-PCIE-E14102 Cisco Emulex OCe14102-FX dual-port 10 GbE FCoE CNA
UCSC-PCIE-Q8362 Cisco Qlogic QLE8362 dual-port 10 GbE FCoE CNA
Switches
Cisco Nexus 93180YC-FX3 1U
Cisco Nexus 93108TC-FX3P 1U fixed switch
Cisco Nexus 9332D-GX2B 1U fixed switch
Cisco Nexus 9364C-GX 2U fixed switch
Optics
QSFP-100G-CWDM4-S Cisco 100GBASE-CWDM4 QSFP28 Optical Transceiver
QSFP-100G-LR4-S Cisco 100GBASE-LR4 QSFP28 Optical Transceiver
QSFP-100G-SR4-S Cisco 100GBASE-SR4 QSFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Hypervisor advisor: which platform fits you mrplanb.com
- VM platform Ledger: hypervisors scored mrplanb.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
Check compatibility with Cisco
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that Cisco has tested with the Cisco HyperFlex HX220c M6.
- Compatibility Cisco UCS Hardware Compatibility List
- Compatibility Cisco Optics-to-Device Compatibility Matrix
- Support Cisco Support and Downloads
Equivalent models from other brands
FAQ
What media was supported on the HX220c M6?
The HX220c M6 supported end-to-end NVMe solid-state storage.
How was the HX220c M6 managed?
Management was provided cloud-natively through Cisco Intersight.
Buying or selling HyperFlex HX220c M6?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- Cisco HyperFlex HX220c M6 Spec Sheet, checked 2026-10-28
- Cisco HyperFlex Express HX220c M6 All NVMe, All Flash and Hybrid Server Node Spec Sheet, checked 2026-10-28