HPE SimpliVity 380 Gen10 G
The HPE SimpliVity 380 Gen10 G is an enhanced hyperconverged solution combining Intel Xeon Scalable Gen2 processing with dense enterprise storage and GPU support. Optimized for virtual desktop infrastructure and graphics-intensive computing workloads, it employs a software-defined deduplication engine that frees PCIe expansion slots for full-height NVIDIA accelerators while maintaining enterprise data efficiency guarantees.
Specifications
| Brand | HPE |
|---|---|
| Family | SimpliVity |
| Form factor | 2U rack |
| Released | Mar 2020 |
| Form factor | 2U rack mount |
| Cpu sockets | 2 |
| Cpu family | Intel Xeon Scalable 2nd Gen (Cascade Lake Refresh) |
| Memory capacity | Up to 3TB DDR4 ECC memory |
| Gpu support | Up to 2 NVIDIA Tesla T4 or V100 GPU accelerators |
| Storage tier | All-flash enterprise SAS SSDs |
| Data protection | Built-in automated rapid backup and restore with 60-second recovery guarantees |
Generations
- Previous generation: HPE SimpliVity 380 Gen10
Works together
How the HPE SimpliVity 380 Gen10 G connects to servers, storage and the network: 1 way, with the parts and products on each path.
Hyperconverged cluster
Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.
Adapters for the server
P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
HPE Aruba CX 8360-32Y4C 1U rack
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX Aruba CX 10000 1U distributed services switch
HPE Aruba CX Aruba CX 9300 1U fixed 400G switch
Optics
QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Hypervisor advisor: which platform fits you mrplanb.com
- VM platform Ledger: hypervisors scored mrplanb.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE SimpliVity 380 Gen10 G.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Equivalent models from other brands
FAQ
What does the 'G' designation signify in the model name?
The G variant includes factory configuration options and thermal profiling specifically tailored for high-density enterprise GPU installations.
Does this model require the hardware PCIe accelerator card?
No, the Gen10 G relies on optimized software deduplication and compression executed across the host Xeon CPU cores.
Buying or selling SimpliVity 380 Gen10 G?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE SimpliVity 380 Gen10 G QuickSpecs (SimpliVity 380 Gen10 G QuickSpecs), checked 2026-10-27
- HPE SimpliVity 380 Gen10 G Overview and Technical Specifications, checked 2026-10-27