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P10111-B21: HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter

HPE P10111-B21 OCP adapterPCIe 3.0 x825GbEOCP 3.0
HPEOCP adaptersPCIe 3.0 x8

Also listed as: P12866-001, P10113-001, MCX562A-ACAI, ConnectX-5-OCP · made by Mellanox

The HPE P10111-B21 is an enterprise dual-port 10/25GbE SFP28 OCP 3.0 mezzanine adapter powered by the Mellanox ConnectX-5 EN controller. Installed into dedicated OCP 3.0 slots on ProLiant Gen10 Plus and Gen11 servers, it delivers hardware RoCE v2, overlay network offloads, and SR-IOV virtualization while preserving all primary and secondary PCIe riser slots. Pre-owned buyers should inspect rear latch levers and test iLO communication.

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Specifications

Part numberP10111-B21
BrandHPE
Made byMellanox
TypeOCP adapters
Other numbersP12866-001, P10113-001, MCX562A-ACAI, ConnectX-5-OCP
Statuscurrent
Speed25GbE
Ports2x SFP28
InterfacePCIe 3.0 x8
Form factorOCP 3.0
ControllerMellanox ConnectX-5 EN
Generation fitGen10 Plus / Gen11

About the P10111-B21

The HPE P10111-B21 brings Mellanox ConnectX-5 10/25GbE performance to the Open Compute Project 3.0 Small Form Factor format. Equipped with dual SFP28 optical ports, it provides wire-speed throughput, hardware-accelerated RoCE v2, and NVMe-oF target and initiator offloading. Designed for high-density compute and storage clustering, it connects directly into the motherboard OCP 3.0 slot on modern ProLiant rack platforms without consuming PCIe slots.

Compatibility

Compatible exclusively with HPE ProLiant Gen10 Plus and Gen11 servers offering OCP 3.0 mezzanine bays, including DL380 Gen10 Plus/Gen11, DL360 Gen10 Plus/Gen11, DL385 Gen11, and DL325 Gen11. It does not fit standard Gen10 non-Plus systems, which use proprietary FlexibleLOM slots. It operates independently of the server PCIe riser cages and requires no riser cards for installation.

How to identify a genuine unit

Genuine cards feature an HPE label marked with Option Part Number P10111-B21, Spare Part Number P12866-001, and Assembly Part Number P10113-001. Silkscreen labeling on the PCB identifies the Mellanox board model as MCX562A-ACAI. In HPE iLO 5 and iLO 6, the device is recognized under Network Information as 'HPE Ethernet 10/25Gb 2-port MCX562A-ACAI OCP3 Adapter'.

Buying used

When evaluating surplus P10111-B21 cards, verify that the OCP ejector handle, retention spring, and locking thumbscrew are completely intact and not bent. Check the gold edge finger contacts for wear. During testing, check that both SFP28 link indicator LEDs light properly upon cable insertion and ensure the card receives and saves firmware updates via the HPE Service Pack for ProLiant (SPP).

Reference prices (last 14 days, updated 2026-10-27)

New: USD 395 (1 sighting, Oct 2026)

Refurbished: USD 195 (1 sighting, Oct 2026)

All sightings
SellerConditionPriceNoteSeen
serversupply.comnewUSD 395New factory sealed retail kit2026-10-27
globalonetechnology.comrefurbishedUSD 195Refurbished genuine OCP card2026-10-27

Prices seen on public listings on the dates shown, before tax and shipping. Not an offer.

Fits these models

Works together

How the HPE P10111-B21 connects to servers, storage and the network: 3 ways, with the hardware on each path.

iSCSI and NVMe/TCP over EthernetFile storage (NFS and SMB)Hyperconverged cluster

iSCSI and NVMe/TCP over Ethernet

Keep the speed the same at all three points: a 25GbE server, a 25GbE switch port and a 25GbE array port. Mixed speeds work but the slowest link sets the pace.

Switches

Storage

Optics

iSCSI and NVMe/TCP over Ethernet: how it fits together

File storage (NFS and SMB)

Front-end ports face the clients; back-end ports (on scale-out systems) connect the nodes to each other and need their own switch pair.

Switches

Storage

Optics

File storage (NFS and SMB): how it fits together

Hyperconverged cluster

Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.

HCI nodes

Switches

Optics

Hyperconverged cluster: how it fits together

Plan and size it

Check compatibility with HPE

Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE P10111-B21.

Equivalent part numbers

FAQ

Does P10111-B21 support NVMe over Fabrics (NVMe-oF)?

Yes, Mellanox ConnectX-5 natively supports NVMe over RDMA (RoCE v2) initiator and target hardware offloads, providing direct storage networking at 25GbE.

What cables work with P10111-B21?

The adapter supports 25GbE SFP28 DAC copper cables, 25GbE optical transceivers with LC fiber, as well as 10GbE SFP+ DAC cables and transceivers.

Buying or selling P10111-B21?

New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.

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Sources