HPE SimpliVity 380 Gen10
The HPE SimpliVity 380 Gen10 is an enterprise 2U hyperconverged node pairing the reliability of the DL380 Gen10 server with the OmniStack data virtualization engine. Available in both hardware-accelerated configurations and software-optimized tiers, the system offers high resiliency, granular backup snapshot schedules, and instantaneous recovery for enterprise virtualization, remote office infrastructure, and virtual desktop deployments.
Specifications
| Brand | HPE |
|---|---|
| Family | SimpliVity |
| Form factor | 2U rack |
| Released | Sep 2017 |
| End of sale | Dec 2022 |
| End of support | Dec 2027 |
| Form factor | 2U rack-mount chassis |
| Cpu sockets | 2 |
| Cpu support | Intel Xeon Scalable 1st and 2nd Gen processors |
| Memory capacity | Up to 3TB DDR4 ECC SmartMemory |
| Storage options | All-flash enterprise SSDs with usable capacity from 6TB to 40TB |
| Hardware acceleration | OmniStack PCIe Accelerator or Software Data Virtualization |
| Hypervisors | VMware vSphere ESXi and Microsoft Windows Server Hyper-V |
Generations
- Previous generation: HPE SimpliVity 380 Gen9
- Next generation: HPE SimpliVity 380 Gen10 G
Works together
How the HPE SimpliVity 380 Gen10 connects to servers, storage and the network: 1 way, with the parts and products on each path.
Hyperconverged cluster
Plan at least two 25GbE ports per node to two switches; all-NVMe clusters often move to 100GbE.
Adapters for the server
P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
HPE Aruba CX Aruba CX 8400 8-slot modular chassis
HPE Aruba CX Aruba CX 8320 1U fixed switch
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX 8360-32Y4C 1U rack
Optics
QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Hypervisor advisor: which platform fits you mrplanb.com
- VM platform Ledger: hypervisors scored mrplanb.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE SimpliVity 380 Gen10.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Equivalent models from other brands
FAQ
Does the SimpliVity 380 Gen10 support Microsoft Hyper-V?
Yes, selected models of the Gen10 platform support Microsoft Hyper-V virtualization alongside traditional VMware vSphere environments.
What is the secondary market demand profile for SimpliVity Gen10 nodes?
Organizations looking to expand existing clusters frequently buy refurbished nodes to avoid full infrastructure replacements while preserving backup policies.
Buying or selling SimpliVity 380 Gen10?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE SimpliVity 380 Gen10 QuickSpecs (SimpliVity 380 Gen10 QuickSpecs), checked 2026-10-27
- HPE SimpliVity 380 Gen10 Overview and Technical Specifications, checked 2026-10-27