HPE ProLiant DL380 Gen12
The HPE ProLiant Compute DL380 Gen12 is the 2U, two socket rack server that follows the DL380 Gen11. It takes Intel Xeon 6 processors and up to 8 TB of DDR5 memory, with PCIe Gen5 risers for GPUs and other accelerators. The front can be built as 8 SFF boxes, with an optional universal media bay or a multipurpose cage that holds EDSFF drives or an NS204i-u boot device. Management moves to iLO 7.
Also written as: DL380 G12, ProLiant DL380 Gen12, ProLiant Compute DL380 Gen12
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon 6 processors, up to 144 E-cores or 86 P-cores per processor |
| Memory type | DDR5 |
| Memory max (GB) | 8,192 |
| Drive bays | 8 SFF boxes with optional universal media bay, optional 4 EDSFF drives in a multipurpose cage |
| Pcie | PCIe Gen5 risers for accelerators |
| Management | HPE iLO 7, HPE Compute Ops Management |
Generations
- Previous generation: HPE ProLiant DL380 Gen11
Compatible parts
Batteries
P01366-B21 HPE 96W Smart Storage Lithium-ion Battery with 145mm Cable Kit
Cables
P02377-B21 HPE Smart Storage Hybrid Capacitor with 145mm Cable Kit
P76471-B21 HPE ProLiant Compute DL380 Gen12 x8 Riser Enablement Cable Kit
Power supplies
P03178-B21 HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit
P38995-B21 HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
P38997-B21 HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
P44712-B21 HPE 1800W-2200W Flex Slot Titanium Hot Plug Power Supply Kit
Network adapters
P25527-B21 HPE DL385 Gen10 Plus 12Gb NVMe 2-port Adapter
P26253-B21 Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
P26259-B21 Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
P51178-B21 Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE
RAID controllers
P47777-B21 HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Storage Controller
P47781-B21 HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller
P47785-B21 HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Storage Controller
P47789-B21 HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller
P74775-B21 HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller
P95072-B21 HPE Smart Array E208e-p SR Gen12 x8 Lanes without Cache SAS 12G PCIe Plug-in Controller
Risers
P48802-B21 HPE ProLiant DL380 Gen11 2U x8/x16/x8 Secondary Riser Kit
P48803-B21 HPE ProLiant DL380 2U x16/x16/x16 Primary Riser Kit
P51083-B21 HPE ProLiant DL380 2U x16/x16/x16 Secondary Riser Kit
Fans
P48820-B21 HPE ProLiant DL380/DL560 Gen11 2U High Performance Fan Kit
P49146-B21 HPE ProLiant DL380 2U Standard Fan Kit
Heatsinks
P49145-B21 HPE ProLiant DL380 2U Standard Heat Sink Kit
SSDs
P63829-B21 HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 CM7 SSD
P63930-B21 HPE 3.84TB NVMe Gen4 Mainstream Performance Very Read Optimized E3S EC1 EDSFF P5430 SSD
P63934-B21 HPE 7.68TB NVMe Gen4 Mainstream Performance Very Read Optimized E3S EC1 EDSFF P5430 SSD
P63938-B21 HPE 15.36TB NVMe Gen4 Mainstream Performance Very Read Optimized E3S EC1 EDSFF P5430 SSD
P79065-B21 HPE 30.72TB NVMe Gen4 Mainstream Performance Very Read Optimized E3S EC1 EDSFF P5430 SSD
P86746-B21 HPE 61.44TB NVMe Gen5 Mainstream Performance Very Read Optimized E3.S EC1 Self-encrypting 6600
P86748-B21 HPE 122.8TB NVMe Gen5 Mainstream Performance Very Read Optimized E3.S EC1 Self-encrypting 6600
Memory
P69726-B21 HPE 16GB (1x16GB) Single Rank x8 DDR5-6400 CAS-52-52-52 EC8 Registered Smart Memory Kit
P69727-B21 HPE 32GB (1x32GB) Dual Rank x8 DDR5-6400 CAS-52-52-52 EC8 Registered Smart Memory Kit
P69728-B21 HPE 64GB (1x64GB) Dual Rank x4 DDR5-6400 CAS-52-52-52 EC8 Registered Smart Memory Kit
P69729-B21 HPE 96GB (1x96GB) Dual Rank x4 DDR5-6400 CAS-52-52-52 EC8 Registered Smart Memory Kit
P69730-B21 HPE 128GB (1x128GB) Dual Rank x4 DDR5-6400 CAS-52-52-52 EC8 Registered Smart Memory Kit
Backplanes
P74743-B21 HPE ProLiant Compute DL3XX Gen12 Rear 2SFF U.3 HDD Stacking Drive Cage Kit
P76449-B21 HPE ProLiant Compute DL3XX Gen12 Multipurpose Drive Cage Kit
P76450-B21 HPE ProLiant Compute Gen12 4EDSFF Drive Cage Kit
OCP adapters
P74758-B21 1 Front Secondary OCP (OCP3.0) (Box 2, Bay
Boot devices
P78279-B21 HPE NS204i-u V2 NVMe Hot Plug Boot Optimized Storage Device
P81160-B21 HPE NS204i-u V2 960GB NVMe Hot Plug Boot Optimized Storage Device
Works together
How the HPE ProLiant DL380 Gen12 connects to servers, storage and the network: 4 ways, with the parts and products on each path.
Fibre Channel SAN
Match the speed: 16Gb and 32Gb FC HBAs, switches and array ports work together, and each generation also runs one or two speeds below its own (a 32Gb port runs at 16Gb and 8Gb).
Adapters for the server (check the fit list)
P9D94A HPE StoreFabric SN1200E 16Gb 2-port Fibre Channel Host Bus Adapter
P9M76A HPE StoreFabric SN1600Q 32Gb 2-port Fibre Channel Host Bus Adapter
Q0L13A HPE StoreFabric SN1600E 32Gb 1-port Fibre Channel Host Bus Adapter
Q0L14A HPE StoreFabric SN1600E 32Gb 2-port Fibre Channel Host Bus Adapter
Switches
HPE StoreFabric SN3600B 1U rack
HPE StoreFabric SN6600B 1U rack
HPE StoreFabric SN6700B 1U rack
Brocade G-Series G610 1U
Storage
HPE Alletra 6000 4U rack
HPE Alletra 9000 4U rack mission-critical array
HPE Alletra Storage MP 2U rack
HPE MSA 1060 2U rack entry SAN
HPE MSA 2060 2U rack
HPE MSA 2062 2U rack hybrid SAN
Optics
R0Q20A HPE MSA 16Gb Short Wave Fibre Channel SFP+ 4-pack Transceivers Gen6
C8R24A HPE MSA 16Gb Short Wave Fibre Channel SFP+ 4-pack Transceivers
57-1000262-01 Brocade 16G FC SFP+ ELWL 25 km
iSCSI and NVMe/TCP over Ethernet
Keep the speed the same at all three points: a 25GbE server, a 25GbE switch port and a 25GbE array port. Mixed speeds work but the slowest link sets the pace.
Adapters for the server
P26253-B21 Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
P26259-B21 Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
Switches
HPE Aruba CX 10000 1U distributed services switch
HPE Aruba CX 8100 1U fixed switch
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX 8360-32Y4C 1U rack
Storage
HPE Alletra 6000 4U rack
HPE Alletra 9000 4U rack mission-critical array
HPE Alletra Storage MP 2U rack
HPE MSA 1060 2U rack entry SAN
HPE MSA 2060 2U rack
HPE MSA 2062 2U rack hybrid SAN
Optics
R0Q21A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers Gen6
C8R23A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers
QSFP-100G-CWDM4-AR Arista 100GBASE-CWDM4 QSFP28 Optical Transceiver Module
Direct-attached SAS
12Gb SAS uses Mini-SAS HD (SFF-8644) connectors; older 6Gb gear uses Mini-SAS (SFF-8088). Adapter cables exist, but the link runs at the slower speed.
Adapters for the server (check the fit list)
804398-B21 HPE Smart Array E208e-p SR Gen10 12G SAS External Controller
726903-B21 HPE H241 12Gb 2-ports Ext Smart Host Bus Adapter
Storage
HPE MSA 2060 2U rack
Dell PowerEdge MX5016s blade
Dell PowerStore NVMe Expansion Enclosure (ENS24) 2U rack
Dell PowerVault ME5012 2U rack
Dell PowerVault ME5024 2U rack
Dell PowerVault ME5084 5U rack
File storage (NFS and SMB)
Front-end ports face the clients; back-end ports (on scale-out systems) connect the nodes to each other and need their own switch pair.
Adapters for the server
P26253-B21 Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
P26259-B21 Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
Switches
HPE Aruba CX 10000 1U distributed services switch
HPE Aruba CX 8100 1U fixed switch
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX 8360-32Y4C 1U rack
Storage
HPE Alletra Storage MP 2U rack
Dell PowerScale A300 4U
Dell PowerScale A3000 4U 4-node chassis
Dell PowerScale F200 1U rack
Dell PowerScale F210 1U node
Dell PowerScale F600 1U rack
Optics
R0Q21A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers Gen6
C8R23A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers
QSFP-100G-CWDM4-AR Arista 100GBASE-CWDM4 QSFP28 Optical Transceiver Module
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- SAN transport and NVMe over FC for backup mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE ProLiant DL380 Gen12.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Buying a used DL380 Gen12: what to check
The model is current in the vendor documentation, so most traded units are new surplus or early lease returns. Check which front cage, riser and power supply options are fitted, because several of them are factory-only on the CTO build. Confirm the iLO 7 licence state and that the unit is not locked to a Compute Ops Management account.
FAQ
Which processors does the DL380 Gen12 use?
Intel Xeon 6 processors with up to 144 E-cores or 86 P-cores per processor, in a two socket 2U chassis.
Which DL380 does the Gen12 replace?
It follows the ProLiant DL380 Gen11 as the 2U two socket general purpose ProLiant.
Buying or selling DL380 Gen12?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL380 Gen12 QuickSpecs, checked 2026-10-28