HPE ProLiant ML350 Gen9
The HPE ProLiant ML350 Gen9 is a premium 5U dual-socket enterprise tower server designed for corporate branch offices and remote data centers requiring high availability and extensive storage expansion. Supporting up to 48 SFF drives, 24 DDR4 DIMM slots, and 9 PCIe expansion slots, it delivers massive scalability and whisper-quiet operation in office environments.
Also written as: ML350 G9, ML350Gen9, ProLiant ML350 Gen 9
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant ML |
| Form factor | tower |
| Released | Sep 2014 |
| End of sale | May 2018 |
| End of support | May 2023 |
| Cpu sockets | 2 |
| Cpu platform | Intel Xeon E5-2600 v3 / v4 series up to 22 cores per socket |
| Memory slots | 24 |
| Memory type | DDR4-2133 / DDR4-2400 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 3,072 |
| Drive bays | Up to 48 SFF or 24 LFF hot-plug SAS/SATA/NVMe |
| Pcie slots | Up to 9 PCIe 3.0 expansion slots |
| Power supply | HPE 500W, 800W, or 1400W Flex Slot Platinum hot-plug |
Generations
- Next generation: HPE ProLiant ML350 Gen10
Compatible parts
Network adapters
647594-B21 HPE Ethernet 1Gb 4-port 331FLR Adapter
652497-B21 HPE Ethernet 1Gb 2-port 361T Adapter
665249-B21 HPE Ethernet 10Gb 2-port 560FLR-SFP+ Adapter
727055-B21 HPE Ethernet 10Gb 2-port 562FLR-SFP+ Adapter
Power supplies
720478-B21 HPE 500W Flex Slot Platinum Hot Plug Power Supply
720479-B21 HPE 800W Flex Slot Platinum Hot Plug Power Supply
720482-B21 HPE 1400W Flex Slot Platinum Plus Hot Plug Power Supply
Memory
726718-B21 HPE 8GB (1x8GB) Single Rank x4 DDR4-2133 CAS-15-15-15 Registered Smart Memory Kit
726719-B21 HPE 16GB (1x16GB) Dual Rank x4 DDR4-2133 CAS-15-15-15 Registered Smart Memory Kit
726720-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2133 CAS-15-15-15 Registered Smart Memory Kit
805349-B21 HPE 16GB (1x16GB) Single Rank x4 DDR4-2400 CAS-17-17-17 Registered Smart Memory Kit
805351-B21 HPE 32GB (1x32GB) Dual Rank x4 DDR4-2400 CAS-17-17-17 Registered Smart Memory Kit
RAID controllers
726821-B21 HPE Smart Array P440/4GB FBWC 12Gb 1-port Int SAS Controller
726907-B21 HPE Smart Array P440ar/2GB FBWC 12Gb 2-ports Int SAS Controller
HBAs
726903-B21 HPE H241 12Gb 2-ports Ext Smart Host Bus Adapter
726911-B21 HPE H240 12Gb 2-ports Int Smart Host Bus Adapter
Batteries
727258-B21 HPE 96W Smart Storage Battery with 145mm Cable for DL/ML/SL Gen9 Servers
Hard drives
765424-B21 HPE 600GB SAS 12G Enterprise 15K SFF (2.5in) SC Enterprise HDD
785067-B21 HPE 300GB SAS 12G Enterprise 10K SFF (2.5in) SC Enterprise HDD
785069-B21 HPE 900GB SAS 12G Enterprise 10K SFF (2.5in) SC Enterprise HDD
Works together
How the HPE ProLiant ML350 Gen9 connects to servers, storage and the network: 4 ways, with the parts and products on each path.
Fibre Channel SAN
Match the speed: 16Gb and 32Gb FC HBAs, switches and array ports work together, and each generation also runs one or two speeds below its own (a 32Gb port runs at 16Gb and 8Gb).
Adapters for the server (check the fit list)
P9D94A HPE StoreFabric SN1200E 16Gb 2-port Fibre Channel Host Bus Adapter
P9M76A HPE StoreFabric SN1600Q 32Gb 2-port Fibre Channel Host Bus Adapter
Q0L13A HPE StoreFabric SN1600E 32Gb 1-port Fibre Channel Host Bus Adapter
Q0L14A HPE StoreFabric SN1600E 32Gb 2-port Fibre Channel Host Bus Adapter
Switches
HPE StoreFabric SN3600B 1U rack
HPE StoreFabric SN6600B 1U rack
HPE StoreFabric SN6700B 1U rack
Cisco MDS 9706 chassis
Storage
HPE StoreEver MSL2024 Tape Library 2U rack tape library
HPE MSA 1040 2U rack entry SAN
HPE MSA 2040 2U rack enterprise SAN
HPE MSA 1050 2U rack entry SAN
HPE MSA 2050 2U rack enterprise SAN
HPE Nimble Storage HF20 4U rack adaptive flash array
Optics
R0Q20A HPE MSA 16Gb Short Wave Fibre Channel SFP+ 4-pack Transceivers Gen6
C8R24A HPE MSA 16Gb Short Wave Fibre Channel SFP+ 4-pack Transceivers
57-1000262-01 Brocade 16G FC SFP+ ELWL 25 km
iSCSI and NVMe/TCP over Ethernet
Keep the speed the same at all three points: a 25GbE server, a 25GbE switch port and a 25GbE array port. Mixed speeds work but the slowest link sets the pace.
Adapters for the server
- 665249-B21 HPE Ethernet 10Gb 2-port 560FLR-SFP+ Adapter
- 727055-B21 HPE Ethernet 10Gb 2-port 562FLR-SFP+ Adapter
Switches
HPE Aruba CX 8400 8-slot modular chassis
HPE Aruba CX 8320 1U fixed switch
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX 8360-32Y4C 1U rack
Storage
- HPE MSA 2040 2U rack enterprise SAN
- HPE MSA 2050 2U rack enterprise SAN
- HPE Nimble Storage HF20 4U rack adaptive flash array
HPE Primera 600 4U rack mission-critical array
HPE MSA 1060 2U rack entry SAN
HPE MSA 2060 2U rack
Optics
R0Q21A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers Gen6
C8R23A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers
QSFP-100G-CWDM4-AR Arista 100GBASE-CWDM4 QSFP28 Optical Transceiver Module
Direct-attached SAS
12Gb SAS uses Mini-SAS HD (SFF-8644) connectors; older 6Gb gear uses Mini-SAS (SFF-8088). Adapter cables exist, but the link runs at the slower speed.
Adapters for the server
- 726903-B21 HPE H241 12Gb 2-ports Ext Smart Host Bus Adapter
Storage
- HPE MSA 2060 2U rack
Dell PowerVault MD1400 2U rack
Dell PowerVault MD1420 2U rack
Dell PowerVault MD3400 2U rack
Dell PowerVault MD3420 2U rack
IBM Storwize V3700 2U rack
File storage (NFS and SMB)
Front-end ports face the clients; back-end ports (on scale-out systems) connect the nodes to each other and need their own switch pair.
Adapters for the server
- 665249-B21 HPE Ethernet 10Gb 2-port 560FLR-SFP+ Adapter
- 727055-B21 HPE Ethernet 10Gb 2-port 562FLR-SFP+ Adapter
Switches
- HPE Aruba CX 8400 8-slot modular chassis
- HPE Aruba CX 8320 1U fixed switch
- HPE Aruba CX 8325-48Y8C 1U rack
- HPE Aruba CX 8360-32Y4C 1U rack
Storage
HPE Alletra Storage MP 2U rack
NetApp FAS Series FAS2520 2U rack
NetApp FAS Series FAS2552 2U rack
NetApp FAS Series FAS8020 3U modular rack
NetApp FAS Series FAS8040 6U modular rack
NetApp FAS Series FAS8060 6U modular rack
Optics
- R0Q21A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers Gen6
- C8R23A HPE MSA 10Gb Short Range iSCSI SFP+ 4-pack Transceivers
- QSFP-100G-CWDM4-AR Arista 100GBASE-CWDM4 QSFP28 Optical Transceiver Module
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- SAN transport and NVMe over FC for backup mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE ProLiant ML350 Gen9.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Equivalent models from other brands
FAQ
What is the maximum drive capacity of an ML350 Gen9?
It can house an industry-established 48 SFF (2.5-inch) or 24 LFF (3.5-inch) SAS/SATA drives.
Can the ML350 Gen9 support GPU accelerators?
Yes, it supports up to 4 dedicated graphics/compute accelerator cards with auxiliary power cables.
Buying or selling ML350 Gen9?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant ML350 Gen9 Server QuickSpecs, checked 2026-10-27