HPE ProLiant DL385 Gen10
The HPE ProLiant DL385 Gen10 is a 2U dual-socket AMD EPYC server designed for virtualization and memory-centric computing. With 32 memory slots and support for up to 24 NVMe drives with dual AMD EPYC processors, it offers substantial memory bandwidth and storage capacity. It serves as a cost-effective platform for hypervisor consolidation in private clouds.
Also written as: DL385 G10, DL385Gen10, ProLiant DL385 Gen 10
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Nov 2017 |
| End of sale | Apr 2020 |
| Cpu sockets | 2 |
| Cpu platform | AMD EPYC 7001 / 7002 series processors up to 64 cores per socket |
| Memory slots | 32 |
| Memory type | DDR4-2666 / DDR4-2933 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 4,096 |
| Drive bays | Up to 30 SFF SAS/SATA or up to 24 NVMe PCIe SSDs |
| Pcie slots | Up to 8 PCIe 3.0 expansion slots |
| Power supply | 500W, 800W, or 1600W Flex Slot Platinum hot-plug |
Generations
- Next generation: HPE ProLiant DL385 Gen10 Plus
Works together
How the HPE ProLiant DL385 Gen10 connects to servers, storage and the network: 4 ways, with the parts and products on each path.
Fibre Channel SAN
Match the speed: 16Gb and 32Gb FC HBAs, switches and array ports work together, and each generation also runs one or two speeds below its own (a 32Gb port runs at 16Gb and 8Gb).
Adapters for the server (check the fit list)
P9D94A HPE StoreFabric SN1200E 16Gb 2-port Fibre Channel Host Bus Adapter
P9M76A HPE StoreFabric SN1600Q 32Gb 2-port Fibre Channel Host Bus Adapter
Q0L13A HPE StoreFabric SN1600E 32Gb 1-port Fibre Channel Host Bus Adapter
Q0L14A HPE StoreFabric SN1600E 32Gb 2-port Fibre Channel Host Bus Adapter
Switches
HPE StoreFabric SN3600B 1U rack
HPE StoreFabric SN6600B 1U rack
HPE StoreFabric SN6700B 1U rack
Brocade G-Series G610 1U
Storage
HPE MSA 1050 2U rack entry SAN
HPE MSA 2050 2U rack enterprise SAN
HPE Nimble Storage Nimble Storage HF20 4U rack adaptive flash array
HPE Primera 600 4U rack mission-critical array
HPE MSA 1060 2U rack entry SAN
HPE MSA 2060 2U rack
Optics
57-1000262-01 Brocade 16Gb Shortwave SFP+ Optical Transceiver
57-1000333-01 Brocade 32Gb Longwave 10km SFP28 Optical Transceiver
57-1000487-01 Brocade 32Gb Shortwave SFP28 Optical Transceiver
iSCSI and NVMe/TCP over Ethernet
Keep the speed the same at all three points: a 25GbE server, a 25GbE switch port and a 25GbE array port. Mixed speeds work but the slowest link sets the pace.
Adapters for the server (check the fit list)
P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
HPE Aruba CX Aruba CX 8400 8-slot modular chassis
HPE Aruba CX Aruba CX 8320 1U fixed switch
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX 8360-32Y4C 1U rack
Storage
- HPE MSA 2050 2U rack enterprise SAN
- HPE Nimble Storage Nimble Storage HF20 4U rack adaptive flash array
- HPE Primera 600 4U rack mission-critical array
- HPE MSA 1060 2U rack entry SAN
- HPE MSA 2060 2U rack
HPE MSA 2062 2U rack hybrid SAN
Optics
QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Direct-attached SAS
12Gb SAS uses Mini-SAS HD (SFF-8644) connectors; older 6Gb gear uses Mini-SAS (SFF-8088). Adapter cables exist, but the link runs at the slower speed.
Adapters for the server (check the fit list)
804398-B21 HPE Smart Array E208e-p SR Gen10 12G SAS External Controller
Storage
- HPE MSA 2060 2U rack
Lenovo ThinkSystem DS4200 2U rack
Dell PowerEdge MX5016s blade
Lenovo ThinkSystem DE2000H 2U rack
Dell PowerVault ME4012 2U rack
Dell PowerVault ME4024 2U rack
File storage (NFS and SMB)
Front-end ports face the clients; back-end ports (on scale-out systems) connect the nodes to each other and need their own switch pair.
Adapters for the server (check the fit list)
- P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
- P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
- P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
- P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
- HPE Aruba CX Aruba CX 8400 8-slot modular chassis
- HPE Aruba CX Aruba CX 8320 1U fixed switch
- HPE Aruba CX 8325-48Y8C 1U rack
- HPE Aruba CX 8360-32Y4C 1U rack
Storage
HPE Alletra Storage MP 2U rack
Dell Unity XT Unity 300 2U rack
Dell Unity XT Unity 400 2U rack
Lenovo ThinkSystem DM3000H 2U rack
Lenovo ThinkSystem DM5000H 2U rack
Lenovo ThinkSystem DM7000H 3U rack
Optics
- QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
- SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
- SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- SAN transport and NVMe over FC for backup mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE ProLiant DL385 Gen10.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Equivalent models from other brands
FAQ
Can the DL385 Gen10 support AMD EPYC Rome processors?
Yes, with updated system ROM, it supports AMD EPYC 7002 series processors in addition to original 7001 Naples CPUs.
How many NVMe SSDs does the DL385 Gen10 support?
It supports up to 24 NVMe SSDs with optional drive cages and riser kits.
Buying or selling DL385 Gen10?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL385 Gen10 Server QuickSpecs, checked 2026-10-27