HPE ProLiant DL385 Gen10 Plus
The HPE ProLiant DL385 Gen10 Plus is a high-performance 2U dual-socket rack server utilizing AMD EPYC 7002 series processors with full PCIe 4.0 enablement. Featuring 32 DDR4-3200 DIMM slots, OCP 3.0 networking, and massive storage options, it provides extensive I/O capacity and memory bandwidth for virtualized environments, data warehousing, and GPU-accelerated computing workloads.
Also written as: DL385 G10 Plus, DL385Gen10Plus, ProLiant DL385 Gen 10 Plus
Specifications
| Brand | HPE |
|---|---|
| Family | ProLiant DL |
| Form factor | 2U rack |
| Released | Mar 2020 |
| End of sale | Jun 2021 |
| Cpu sockets | 2 |
| Cpu platform | AMD EPYC 7002 series processors up to 64 cores per socket |
| Memory slots | 32 |
| Memory type | DDR4-3200 SmartMemory RDIMM / LRDIMM |
| Memory max (GB) | 4,096 |
| Drive bays | Up to 32 SFF SAS/SATA/NVMe or up to 20 LFF SAS/SATA |
| Pcie slots | Up to 8 PCIe 4.0 expansion slots plus OCP 3.0 |
| Power supply | 500W, 800W, or 1600W Flex Slot Platinum hot-plug |
Generations
- Previous generation: HPE ProLiant DL385 Gen10
- Next generation: HPE ProLiant DL385 Gen10 Plus v2
Works together
How the HPE ProLiant DL385 Gen10 Plus connects to servers, storage and the network: 4 ways, with the parts and products on each path.
Fibre Channel SAN
Match the speed: 16Gb and 32Gb FC HBAs, switches and array ports work together, and each generation also runs one or two speeds below its own (a 32Gb port runs at 16Gb and 8Gb).
Adapters for the server (check the fit list)
P9D94A HPE StoreFabric SN1200E 16Gb 2-port Fibre Channel Host Bus Adapter
P9M76A HPE StoreFabric SN1600Q 32Gb 2-port Fibre Channel Host Bus Adapter
Q0L13A HPE StoreFabric SN1600E 32Gb 1-port Fibre Channel Host Bus Adapter
Q0L14A HPE StoreFabric SN1600E 32Gb 2-port Fibre Channel Host Bus Adapter
Switches
HPE StoreFabric SN6700B 1U rack
HPE StoreFabric SN3600B 1U rack
HPE StoreFabric SN6600B 1U rack
Brocade G-Series G720 1U
Storage
HPE MSA 1060 2U rack entry SAN
HPE MSA 2060 2U rack
HPE MSA 2062 2U rack hybrid SAN
HPE Alletra 6000 4U rack
HPE Alletra 9000 4U rack mission-critical array
HPE Primera 600 4U rack mission-critical array
Optics
57-1000262-01 Brocade 16Gb Shortwave SFP+ Optical Transceiver
57-1000333-01 Brocade 32Gb Longwave 10km SFP28 Optical Transceiver
57-1000487-01 Brocade 32Gb Shortwave SFP28 Optical Transceiver
iSCSI and NVMe/TCP over Ethernet
Keep the speed the same at all three points: a 25GbE server, a 25GbE switch port and a 25GbE array port. Mixed speeds work but the slowest link sets the pace.
Adapters for the server (check the fit list)
P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
HPE Aruba CX 8360-32Y4C 1U rack
HPE Aruba CX 8325-48Y8C 1U rack
HPE Aruba CX Aruba CX 10000 1U distributed services switch
HPE Aruba CX Aruba CX 9300 1U fixed 400G switch
Storage
- HPE MSA 1060 2U rack entry SAN
- HPE MSA 2060 2U rack
- HPE MSA 2062 2U rack hybrid SAN
- HPE Alletra 6000 4U rack
- HPE Alletra 9000 4U rack mission-critical array
- HPE Primera 600 4U rack mission-critical array
Optics
QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Direct-attached SAS
12Gb SAS uses Mini-SAS HD (SFF-8644) connectors; older 6Gb gear uses Mini-SAS (SFF-8088). Adapter cables exist, but the link runs at the slower speed.
Adapters for the server (check the fit list)
804398-B21 HPE Smart Array E208e-p SR Gen10 12G SAS External Controller
Storage
- HPE MSA 2060 2U rack
Dell PowerEdge MX5016s blade
Dell PowerVault ME5012 2U rack
Dell PowerVault ME5024 2U rack
Dell PowerVault ME5084 5U rack
Lenovo ThinkSystem DE2000H 2U rack
File storage (NFS and SMB)
Front-end ports face the clients; back-end ports (on scale-out systems) connect the nodes to each other and need their own switch pair.
Adapters for the server (check the fit list)
- P08443-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 Adapter
- P10111-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX562A-ACAI OCP3 Adapter
- P10112-B21 HPE Ethernet 10/25Gb 2-port SFP28 MCX512F-ACHT Adapter
- P10115-B21 HPE Ethernet 10/25Gb 2-port SFP28 BCM57414 OCP3 Adapter
Switches
- HPE Aruba CX 8360-32Y4C 1U rack
- HPE Aruba CX 8325-48Y8C 1U rack
- HPE Aruba CX Aruba CX 10000 1U distributed services switch
- HPE Aruba CX Aruba CX 9300 1U fixed 400G switch
Storage
HPE Alletra Storage MP 2U rack
Dell PowerScale F200 1U rack
Dell PowerScale F600 1U rack
Dell PowerStore 1000T 2U rack
Dell PowerStore 1000X 2U rack
Dell PowerStore 3000T 2U rack
Optics
- QSFP-100G-SR4 Arista 100GBASE-SR4 QSFP28 Optical Transceiver
- SFP-10G-SR-AR Arista 10GBASE-SR SFP+ Optical Transceiver
- SFP-25G-SR Arista 25GBASE-SR SFP28 Optical Transceiver
Plan and size it
- Draw this setup in the topology planner mrplanb.com
- Add up rack power and space rack-density.com
- Virtualization storage Ledger: scored storage platforms mrplanb.com
- SAN transport and NVMe over FC for backup mrplanb.com
- HPE SPOCK (HPE storage compatibility) hpe.com
Check compatibility with HPE
Before you buy, confirm the exact configuration against the vendor's own lists: firmware levels, operating systems, adapters and optics that HPE has tested with the HPE ProLiant DL385 Gen10 Plus.
- Compatibility HPE SPOCK (storage, SAN and host compatibility)
- Part lookup HPE PartSurfer (spare and option part numbers)
- Support HPE Support Center
Equivalent models from other brands
FAQ
What PCIe generation is supported in the DL385 Gen10 Plus?
It supports PCIe 4.0 across all expansion slots, doubling bandwidth compared to Gen3 platforms.
What GPU cards are supported in the DL385 Gen10 Plus?
It supports up to 3 double-wide or 8 single-wide PCIe accelerator GPUs for compute-heavy workloads.
Buying or selling DL385 Gen10 Plus?
New, refurbished or used. Tell us the quantity and condition and we connect you with a vetted reseller in your region, usually within one working day.
Sources
- HPE ProLiant DL385 Gen10 Plus Server QuickSpecs, checked 2026-10-27